Education

• 2005/08 - 2011/07: PhD. Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University 
• 2003/08 - 2005/07: MS. Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University
• 1999/09 - 2003/06: BS. Department of Medical Technology, College of Medicine, National Taiwan University

Affiliation: 2021/02 - Associate Professor, Kaohsiung Medical University

• 2014/08 -2021/01:  Assistant Professor, Kaohsiung Medical University
• 2012/10 – 2014/07: Postdoctoral scholar. Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
• 2012/04 - 2012/09: Postdoctoral scholar. International Medical Education and Research Center, Niigata, Japan
• 2011/09 - 2012/03: Postdoctoral scholar. Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan

Publication (2014-2021)

1.      Chen YH, Lin SY, Lin YT, Tseng SP, Chang CC, Yu SY, Hung WW, Jao YT, Lin CY, Hung WC*. 2021. Emergence of aac(6')-Ie-aph(2'')-Ia-positive enterococci with non-high-level gentamicin resistance mediated by IS1216V: adaptation to decreased aminoglycoside usage in Taiwan. J Antimicrob Chemother. 76:1689–1697.

2.      Yang TY, Tseng SP, Dlamini HN, Lu PL, Lin L, Wang LC, Hung WC*. 2021. In vitro and In vivo activity of AS101 against carbapenem-resistant Acinetobacter baumannii. Pharmaceuticals (Basel) 14:823.

3.      Wan TW, Liu YJ, Wang YT, Lin YT, Hsu JC, Tsai JC, Chiu HC, Hsueh PR, Hung WC*, Teng LJ*. 2021. Potentially conjugative plasmids harboring Tn6636, a multidrug-resistant and composite mobile element, in Staphylococcus aureus. J Microbiol Immunol Infect.In press.

4.      Lin SY, Hung WC, Lo SH, Tseng YT, Lu PL*. 2021. Successful treatment with daptomycin and ceftaroline of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) endocarditis: a case report. Journal of Global Antimicrobial Resistance. 27:335-336. 

5.      Tsai HJ, Tsai YC, Hung WW, Hung WC, Chang CC, Dai CY. 2021. Gut microbiota and non-alcoholic fatty liver disease severity in type 2 diabetes patients. J Pers Med 11:238.

6.      Lin YT, Lin TY, Hung SC, Liu PY, Wu PH, Chuang YS, Hung WC, Chiu YW, Kuo MC, Wu CY*. 2021. Anti-acid drug treatment induces changes in the gut microbiome composition of hemodialysis patients. Microorganisms 9:286.

7.       Lin YT, Lin TY, Hung SC, Liu PY, Hung WC, Tsai WC, Tsai YC, Delicano RA, Chuang YS, Kuo MC, Chiu YW, Wu PH. 2021. Differences in the microbial composition of hemodialysis patients treated with and without beta-blockers. J Pers Med 11:198.

8.      Hung WW, Peng P, Tsai YC, Jhou PS, Chang CC, Hsieh CC, Su YC, Dai CY, Hung WC*. 2021. Gut microbiota compositions and metabolic functions in type 2 diabetes differ with glycemic durability to metformin monotherapy. Diabetes Res Clin Pract 174:108731.

9.   Hung WC, Hung WW, Tsai HJ, Chang CC, Chiu YW, Hwang SJ, Kuo MC, Chen SC, Dai CY, Tsai YC*. 2021. The association of targeted gut microbiota with body composition in type 2 diabetes mellitus. International Journal of Medical Sciences 18:511-519.

10.   Wu PH, Liu PY, Chiu YW, Hung WC, Lin YT, Lin TY, Hung SC, Delicano RA, Kuo MC, Wu CY. 2020. Comparative gut microbiome differences between ferric citrate and calcium carbonate phosphate binders in patients with end-stage kidney disease. Microorganisms 8:2040.

11.   Hung WW, Hung WC*. 2020. How gut microbiota relate to the oral antidiabetic treatment of type 2 diabetes. Medicine in Microecology. 3: 100007

12.   Lin YT, Tseng SP, Hung WW, Chang CC, Chen YH, Jao YT, Chen YH, Teng LJ, Hung WC*. 2020. A possible role of insertion sequence IS1216V in dissemination of multidrug-resistant elements MES_PM1 and MES_6272-2 between Enterococcus and ST59 Staphylococcus aureus. Microorganisms 8:1905.

13.  Jhong YT, Chao CY, Hung WC, Du JK. 2020. Effects of various polishing techniques on the surface characteristics of the Ti-6Al-4V alloy and on bacterial adhesion. Coatings 10:1057.

14.  Su YC, Hung WW, Lin JM, Chang CC, Chen YH, Lai YL, Tseng SP, Lu PL, Yamamoto T, Teng LJ, Hung WC*. 2020. Tracking the evolution of the two successful CC59 methicillin-resistant Staphylococcus aureus clones in Taiwan: the divergence time of the two clades is estimated to be the 1980s. International Journal of Antimicrobial Agents 56:106047

15.   Hung WW, Chen YH, Tseng SP, Jao YT, Teng LJ, Hung WC*. 2019. Using groEL as the target for identification of Enterococcus faecium clades and 7 clinically relevant Enterococcus species. Journal of Microbiology, Immunology and Infection 52:255-264.

16.  Lin YT, Hung WC, Tsai JC, Leong KH, Chen HJ, Hsueh PR, Teng LJ. 2018. Wide dissemination of SCCfusC in fusidic acid-resistant coagulase-negative staphylococci and implication for its spread to methicillin-resistant Staphylococcus aureus in Taiwan. International Journal of Antimicrobial Agents 51:775–880.

17.   Wan TW, Higuchi W, Khokhlova OE, Hung WC, Iwao Y, Wakayama M, Inomata N, Takano T, Lin YT, Peryanova OV, Kojima KK, Salmina AB, Teng LJ, Yamamoto T. 2017. Genomic comparison between Staphylococcus aureus GN strains clinically isolated from a familial infection case: IS1272 transposition through a novel inverted repeat-replacing mechanism. PLoS One 12:e0187288.

18.  Lin L, Wang SF, Yang TY, Hung WC, Chan MY, Tseng SP. 2017. Antimicrobial resistance and genetic diversity in ceftazidime non-susceptible bacterial pathogens from ready-to-eat street foods in three Taiwanese cities. Scientific Reports 7:15515.

19.  Tseng SP, Hung WC, Chen HJ, Lin YT, Jiang HS, Chiu HC, Hsueh PR, Teng LJ, Tsai JC. 2017. Effects of toluidine blue O (TBO)-photodynamic inactivation on community-associated methicillin-resistant Staphylococcus aureus isolates. Journal of Microbiology, Immunology and Infection 49:46-54.

20.  Yang TY, Hung WW, Lin L, Hung WC, Tseng SP. 2017. mecA-related structure in methicillin-resistant coagulase-negative staphylococci from street food in Taiwan. Scientific Reports 7:42205.

21.  Hung WC, Wan TW, Kuo YC, Yamamoto T, Tsai JC, Lin YT, Hsueh PR, Teng LJ. 2016. Molecular evolutionary pathways toward two successful community-associated but multidrug-resistant ST59 methicillin-resistant Staphylococcus aureus lineages in Taiwan: Dynamic modes of mobile genetic element salvages. PLoS One 11:e0162526.

22.  Wan TW, Hung WC, Tsai JC, Lin YT, Lee H, Hsueh PR, Lee TF, Teng LJ. 2016. Novel structure of Enterococcus faecium-originated ermB positive Tn1546-like in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 60:6108-6114.

23.  Tseng SP, Hung WC, Huang CY, Lin YS, Chan MY, Lu PL, Lin L, Sheu JH. 2016. 5-Episinuleptolide decreases the expression of the extracellular matrix in early biofilm formation of multi-drug resistant Acinetobacter baumannii. Marine Drugs 14:pii: E143.

24.  Chen HJ, Lin YT, Hung WC, Tsai JC, Hsueh PR, Teng LJ. 2016. Distribution of staphylococcal cassette chromosome (SCC) mec element types in fusidic acid-resistant Staphylococcus epidermidis and identification of a novel SCC7684 element. Antimicrobial Agents and Chemotherapy 60:5006-5009.

25.  Lin YT, Tsai JC, Yamamoto T, Chen HJ, Hung WC, Hsueh PR, Teng LJ. 2016. Emergence of a small colony variant of vancomycin-intermediate Staphylococcus aureus in a patient with septic arthritis during long-term treatment with daptomycin. Journal of Antimicrobial Chemotherapy 71:1807-1814.

26.  Wan TW, Tomita Y, Saita N, Konno K, Iwao Y, Hung WC, Teng LJ, Yamamoto T. 2016. Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly. New Microbes New Infect 13:17-21.

27.   Hung WC, Chen HJ, Lin YT, Tsai JC, Chen CW, Lu HH, Tseng SP, Jheng YY, Leong KH, Teng LJ. 2015. Skin commensal staphylococci may act as reservoir for fusidic acid resistance genes. PLoS One 10:e0143106.

28.   Sawanobori E*, Hung WC*, Takano T, Hachuda K, Horiuchi T, Higuchi W, Hung WW, Iwao Y, Nishiyama A, Reva I, Reva G, Teng LJ, Yamamoto T. 2015. Emergence of Panton-Valentine leukocidin-positive ST59 methicillin-susceptible Staphylococcus aureus with high cytolytic peptide expression in association with community-acquired pediatric osteomyelitis complicated by pulmonary embolism. Journal of Microbiology, Immunology and Infection 48:565-573.

29.   Khokhlova OE, Hung WC, Wan TW, Iwao Y, Takano T, Higuchi W, Yachenko SV, Teplyakova OV, Kamshilova VV, Kotlovsky YV, Nishiyama A, Reva IV, Sidorenko SV, Peryanova OV, Reva GV, Teng LJ, Salmina AB, Yamamoto T. 2015. Healthcare- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) and fatal pneumonia with pediatric deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's multiple virulence factors, genome, and stepwise evolution. PLoS One 10:e0128017.

30.   Chen HJ, Hung WC,Lin YT,Tsai JC Chiu HC, Hsueh PR, and Teng LJ. 2015. A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohnii. Journal of Antimicrobial Chemotherapy 70: 416-419.

31.   Khokhlova O, Tomita Y, Hung WC, Takano T, Iwao Y, Higuchi W, Nishiyama A, Reva I, and Yamamoto T. 2015. Elderly infection in the community due to ST5/SCCmecII methicillin-resistant Staphylococcus aureus (the New York/Japan clone) in Japan: Panton-Valentine leukocidin-negative necrotizing pneumonia. Journal of Microbiology, Immunology and Infection 48: 335-339.

32.   Tseng SP, Wang SF, Kuo CY, Huang JW, Hung WC, Ke GM, Lu PL. 2015. Characterization of fosfomycin resistant extended-spectrum beta-lactamase-producing Escherichia coli isolates from human and pig in Taiwan. PLoS One 10:e0135864.

33.   Tseng SP, Lin YT, Tsai JC, Hung WC, Chen HJ, Chen PF, Hsueh PR, and Teng LJ. 2015. Genotypes and phenotypes of Staphylococcus lugdunensis isolates recovered from bacteremia. Journal of Microbiology, Immunology and Infection 48:397-405.

34.   Hung WC, Chen HJ, Tsai JC, Tseng SP, Lee TF, Hsueh PR, Shieh WY, and Teng LJ. 2014. Gemella parahaemolysans sp. nov. and Gemella taiwanensis sp. nov., isolated from human clinical specimens. International Journal of Systematic and Evolutionary Microbiology 64: 2060-2065.