師資介紹

學歷

• 高雄醫學大學 醫學研究所 博士
• 高雄醫學大學 醫學研究所 碩士

經歷

• 高雄醫學大學 微生物學科 主任(現職)
• 高雄醫學大學 微生物學科 教授

研究方向

1. 幽門桿菌致癌之致病機轉(包括宿主免疫反應及幽門桿菌毒性因子之探討)
2. 神經疼痛之分子機制及藥物治療之研究(免疫細胞及神經細胞在神經疼痛中所扮演之角色)

歷年研究成果目錄

1. Lin JN, Chang LL, Lai CH, Lin HH, Chen YH. Clinical and Molecular Characteristics of Invasive and Noninvasive Skin and Soft-Tissue Infections Caused by Group A Streptococcus. J Clin Microbiol. 2011 Aug 24
2. Lin HH, Ke HL, Hsiao KH, Tsai CW, Wu WJ, Bau DT, Chang LL. Potential role of CCND1 G870A genotype as a predictor for urothelial carcinoma susceptibility and muscle-invasiveness in Taiwan. Chin J Physiol. 2011 Jun 30;54(3):196-202
3. Cheng KI, Wang HC, Lai CS, Tsai HP, Kwan AL, Ho ST, Wang JJ, Chang LL. Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain. J Pharm Pharmacol. 2011 Aug;63(8):1063-9.
4. Cheng KI, Lai CS, Wang FY, Wang HC, Chang LL, Ho ST, Tsai HP, Kwan AL. Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3 expression and decreasing spinal microglial activation. BMC Neurol. 2011 Jun 16;11:71
5. Lin HH, Ke HL, Hsiao KH, Tsai CW, Wu WJ, Bau DT, Chang LL. CCND1 1722 polymorphism and potential relevance to upper tract urothelial cancer. Anticancer Res. 2011 Mar;31(3):1043-7
6. Lin JN, Lai CH, Chen YH, Chang LL, Lee SS, Lin HH. Immune reconstitution inflammatory syndrome presenting as chylothorax in a patient with HIV and Mycobacterium tuberculosis coinfection: a case report. BMC Infect Dis. 2010 Nov 8;10:321.
7. Lin JN, Lai CH, Chen YH, Chang LL, Lu PL, Tsai SS, Lin HL, Lin HH. Characteristics and outcomes of polymicrobial bloodstream infections in the emergency department: A matched case-control study. Acad Emerg Med. 2010 Oct;17(10):1072-9.
8. Chang CY, Lu PL, Lin CC, Lee TM, Tsai MY, Chang LL*. Integron types, gene cassettes, antimicrobial resistance genes and plasmids of Shigella sonnei isolates from outbreaks and sporadic cases in Taiwan. J Med Microbiol. 2011 Feb;60(Pt 2):197-204
9. Lin HH, Ke HL, Wu WJ, Lee YH, Chang LL*. Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection. Urol Oncol. 2010 Aug 25. [Epub ahead of print]
10. Lai CH, Lin JN, Chang LL, Chen YH, Lin HH. Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. BMC Infect Dis. 2010 Jul 1;10:193.
11. Chan HC, Ke LY, Liu CC, Chang LL, Tsai WC, Liu HW, Yen JH. Increased expression of suppressor of cytokine signaling 1 mRNA in patients with rheumatoid arthritis. Kaohsiung J Med Sci. 2010 Jun;26(6):290-8.
12. Yeh HC, Huang CH, Yang SF, Li CC, Chang LL, Lin HH, Ke HL, Wei YC, Wu WJ. Nuclear factor-κB activation predicts an unfavourable outcome in human Upper urinary tract urothelial carcinoma. BJU Int. 2010 Oct;106(8):1223-9.
13. Chan HC, Ke LY, Chang LL, Liu CC, Hung YH, Lin CH, Li RN, Tsai WC, Liu HW, Yen JH. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. Lupus. 2010 May;19(6):696-702.
14. Lai CH, Chen YH, Lin JN, Chang LL, Chen WF, Lin HH. Acute Q fever and scrub typhus, southern Taiwan. Emerg Infect Dis. 2009 Oct;15(10):1659-61
15. Lai CH, Huang CK, Chen YH, Chang LL, Weng HC, Lin JN, Chung HC, Liang SH, Lin HH. Epidemiology of acute q Fever, scrub typhus, and murine typhus, and identification of their clinical characteristics compared to patients with acute febrile illness in southern taiwan. J Formos Med Assoc. 2009 May;108(5):367-76.
16. Tan LB, Chang LL, Cheng KI, Huang CH, Kwan AL. Transitional cell carcinomas of the renal pelvis and the ureter: comparative demographic characteristics, pathological grade and stage and 5-year survival in a Taiwanese population. BJU Int. 2009 Feb;103(3):312-6.
17. Ke HL, Chang LL, Yang SF, Lin HH, Li CC, Wu DC, Wu WJ. Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma. Urol Oncol. 2009 Dec 16.
18. Kuo CH, Hu HM, Tsai PY, Wu IC, Yang SF, Chang LL, Wang JY, Jan CM, Wang WM, Wu DC. Short-term celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. World J Gastroenterol. 2009 Oct 21;15(39):4907-14.
19. Chang CY, Fang YT, Tsai SM, Chang LL, Yu WL. Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan. Diagn Microbiol Infect Dis. 2009 Oct;65(2):214-6.
20. Tseng YS, Wu DC, Chang CY, Kuo CH, Yang YC, Jan CM, Su YC, Kuo FC, Chang LL. Amoxicillin resistance with beta-lactamase production in Helicobacter pylori. Eur J Clin Invest. 2009 Sep;39(9):807-12.
21. Cheng KI, Lin SR, Chang LL, Wang JY, Lai CS. Association of the functional A118G polymorphism of OPRM1 in diabetic patients with foot ulcer pain. J Diabetes Complications. 2010 Mar-Apr;24(2):102-8.
22. Kuo CH, Hu HM, Kuo FC, Hsu PI, Chen A, Yu FJ, Tsai PY, Wu IC, Wang SW, Li CJ, Weng BC, Chang LL, Jan CM, Wang WM, Wu DC. Efficacy of levofloxacin-based rescue therapy for Helicobacter pylori infection after standard triple therapy: a randomized controlled trial. J Antimicrob Chemother. 2009 May;63(5):1017-24.
23. Chang KP, Lai CH, Huang SH, Tai HT, Chang LL, Lin SD, Hwang SL, Lai CS. Downregulation of Janus kinase 3 expression by small interfering RNA in rat composite tissue allotransplantation. Transpl Immunol. 2009 May;21(1):27-32.
24. Lin HH, Ke HL, Huang SP, Wu WJ, Chen YK, Chang LL. Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine. Urol Oncol. 2010 Nov-Dec;28(6):597-602.
25. Lee YC, Lin HH, Wang CJ, Liu CC, Wu WJ, Huang CH, Chang LL. The associations among GNB3 C825T polymorphism, erectile dysfunction, and related risk factors. J Sex Med. 2008 Sep;5(9):2061-8.
26. Kuo CH, Hu HM, Tsai PY, Yang SF, Chang LL, Wang JY, Chen A, Jan CM, Wang WM, Wu DC. A better method for confirming Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol. 2008;43(1):32-7.
27. Chang KP, Huang SH, Lin CL, Chang LL, Lin SD, Lai CS. An alternative model Of composite tissue allotransplantation: groin-thigh flap. Transpl Int. 2008 Jun;21(6):564-71.
28. Chang LL, Lin HH, Chang CY, Lu PL. Increased incidence of class 1 integrons in trimethoprim/ sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother. 2007 May;59(5):1038-9
29. Chang TM, Lu PL, Li HH, Chang CY, Chen TC, Chang LL. Characterization of fluoroquinolone resistance mechanisms and their correlation with the degree of resistance to clinically used fluoroquinolones among Escherichia coli isolates. J Chemother. 2007 Oct;19(5):488-94.
30. Kuo CH, Yu FJ, Tsai PY, Yang SF, Chang LL, Jan CM, Wang WM, Wu DC. Evaluating the validity of the serologic test for detecting Helicobacter pylori infection in Mongolian gerbils. Kaohsiung J Med Sci. 2007 Nov;23(11):545-51.
31. Lee YC, Huang CH, Wang CJ, Liu CC, Wu WJ, Chang LL, Lin HH. The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int. 2007 Nov;100(5):1116-20.
32. Chang LL, Chang TM, Chang CY. Variable gene cassette patterns of class 1 integron-associated drug-resistant Escherichia coli in Taiwan. Kaohsiung J Med Sci. 2007 Jun;23(6):273-80.
33. Lu CY, Kuo FC, Wang SW, Lo YC, Wu IC, Chang LL, Yu FJ, Su YC, Wang WM, Jan CM, Wu DC. The clinical applications and accuracy of 2 rapid near-patient Tests in detecting Helicobacter pylori infection. Diagn Microbiol Infect Dis. 2006 Nov;56(3):241-6.
34. Wu IC, Wang SW, Yang YC, Yu FJ, Kuo CH, Chuang CH, Lee YC, Ke HL, Kuo FC, Chang LL, Wang WM, Jan CM, Wu DC. Comparison of a new office-based Stool immunoassay and (13)C-UBT in the diagnosis of current Helicobacter pylori infection. J Lab Clin Med. 2006 Mar;147(3):145-9.