萬采玟老師

連絡電話:07-312-1101 ext.2150-23

  • 電子信箱:tsaiwenwan@kmu.edu.tw
  • 辦公位置:醫學研究大樓 3 樓 341室
  • 專長領域:微生物學、分子生物學、基因體學  

學歷

  • 國立台灣大學 醫學檢驗暨生物技術學系 博士
  • 國立台灣大學 醫學檢驗暨生物技術學系 碩士
  • 國立高雄師範大學 生物科技系 學士

經歷

  • 高雄醫學大學 醫學系微生物暨免疫學科 助理教授 (現職)
  • 國立台灣大學 醫學檢驗暨生物技術學系  研究學者 
  • 國立台灣大學 醫學檢驗暨生物技術學系  博士後研究員 


參與課程

  • 微生物免疫學相關課程之教學

   微生物基因體學

學術著作 (2015-2025)

1.    Tsai-Wen Wan, Yusuke Tomita, Emi Sawanobori, Natsuko Ishitobi, Kenji K Kojima, Tetsuya Matsumoto, Hiromu Takemura, Masaki Shintani, Wei-Chun Hung, Yu-Ting Wang, Lee-Jene Teng, Tatsuo Yamamoto*. (2025, Nov). Role of virulence plasmid p32kb with citA or citABC in severe invasive infections of community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl. Journal of Microbiology, Immunology and Infection, S1684-1182(25)00193-8. (SCI, 5Y IF= 3.7; 35/137, Infectious Diseases). 本人為第一作者.

2.    Tsai-Wen Wan, Masaki Shintani, Kenji K Kojima, Naohiko Moriguchi, Wei-Chun Hung, Yu-Ting Wang, Lee-Jene Teng, Tatsuo Yamamoto*. (2025, Oct). Transposition of Tn552-II (a Tn552 derivative) to the conjugative pCtra plasmid family in pediatric multidrug-resistant community-associated MRSA. Antimicrobial Agents and Chemotherapy, 69(10):e0064725. (SCI, 5Y IF= 4.4; 38/163, Microbiology). 本人為第一作者.

3.    Lee Tai-Fen, Wan Tsai-Wen, Hsu Wei-Yu, Chen Xiang-Jun, Chiu Hao-Chieh*, Huang Yu-Tsung*. (2025, Apr). Comparison of a Sepsityper® kit and in-house membrane filtration methods for rapidly diagnosing positive blood cultures via MALDI‒TOF MS. Journal of Microbiology, Immunology and Infection, 58(2):265-271. (SCI, 5Y IF= 3.7; 35/137, Infectious Diseases). NSTC 111-2326-B-002-011-MY3. 本人為共同第一作者.

4.    Tsai-Wen Wan, Yu-Tsung Huang, Jian-Hong Lai, Qiao-Ting Chao, Hui-Hui Yeo, Tai-Fen Lee, Yung-Chi Chang, Hao-Chieh Chiu*. (2024, Sep). The emergence of transposon-driven multidrug resistance in invasive nontypeable Haemophilus influenzae over the last decade. International Journal of Antimicrobial Agents, 64(4):107319. (SCI, 5Y IF=5.6; 7/132, Infectious Diseases). NSTC 111-2326-B-002-011-MY3. 本人為共同第一作者.

5.    Tsai-Wen Wan, Tai-Fen Lee, Xiang-Jun Chen, Yun-Tsung Hunag, Lee-Jene Teng, Po-Ren Hsueh, Hao-Chieh Chiu*. (2023, Dec). Performance assessment of the Bruker Biotyper MALDI-TOF MS for the identification of difficult-to-identify viridans group streptococci. Journal of Clinical Microbiology, 61(12):e0114323. (SCI, 5Y IF=5.8; 19/161, Microbiology). NSTC 111-2326-B-002-011-MY3. 本人為共同第一作者.

6.    Xiang-Jun Chen, Tsai-Wen Wan, Qiuo-Ting Chao, Lee-Jene Teng, Tai-fen Lee*, Yu-Tsung Huang, Po-Ren Hsueh*. (2023, Jun). Applicability of an in-house extraction protocol in a Bruker Biotyper matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system for the identification of Streptococcus agalactiae from broth-enriched vaginal/rectal swab specimens. Journal of Microbiology Immunology and Infection, 56(4):815-821. (SCI, 5Y IF=4.1; 23/132, Infectious Diseases).

7.    Tsai-Wen Wan, Hui-Hui Yeo, Tai-Fen Lee, Yu-Tsung Huang, Po-Ren Hsueh, Hao-Chieh Chiu*. (2022, Dec). Molecular epidemiology of bacteraemic vancomycin-resistant Enterococcus faecium isolates and in vitro activities of SC5005 and other comparators against these isolates collected from a medical centre in northern Taiwan, 2019-2020. Journal of Antimicrobial Chemotherapy, 78(2):457-465. (SCI, 5Y IF=5.4; 24/129, Infectious Diseases). MOST 110-2628-B-002-038. 本人為第一作者.

8.    Tsai-Wen Wan, Yu-Jung Liu, Yu-Ting Wang, Yu-Tzu Lin, Jia-Chuan Hsu, Jui-Chang Tsai, Hao-Chieh Chiu, Po-Ren Hsueh, Wei-Chun Hung*, Lee-Jene Teng* (2021, Mar). Potentially conjugative plasmids harboring Tn6636, a multidrug-resistant and composite mobile element, in Staphylococcus aureus. Journal of Microbiology Immunology and Infection, 55(2):225-233. (SCI, 5Y IF=5.845; 19/124, Infectious Diseases). 本人為第一作者.

9.    Tsai-Wen Wan, Lee Jene Teng, Tatsuo Yamamoto* (2020, Oct). Unique surface structures of community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl. Journal of Microbiology Immunology and Infection, 54(3):527-530. (SCIE, IF=3.376; 27/93, Infectious Diseases). 本人為第一作者.

10. Jia-Chuan Hsu, Tsai-Wen Wan, Hao Lee, Xiao-Mei Wang, Yu-Tzu Lin, Chiau-Jing Jung, Tai-Fen Lee, Po-Ren Hsueh, Lee-Jene Teng* (2020, Jul). Heterogeneity of molecular characteristics among Staphylococcus argenteus clinical isolates (ST2250, ST2793, ST1223, and ST2198) in northern Taiwan. Microorganisms, 8(8), 1157. (SCIE, IF=4.152; 37/136, Microbiology). MOST 106-2320-B-002-039-MY3. MOST 106-2320-B-002-039-MY3. 本人為共同第一作者.

11. Yu-Ting Wang, Yu-Tzu Lin, Tsai-Wen Wan, Der-Yuan Wang, Hsu-Yang Lin, Che-Yang Lin, Yu-Chih Chen, Lee Jene Teng* (2019, Oct). Distribution of antibiotic resistance genes among Staphylococcus species isolated from ready-to-eat foods. Journal of Food and Drug Analysis, 27(4), 841-848. (SCI, IF=5.316; 13/135, Food science & Technology). MOST 106-2320-B-002-039-MY3.

12. Tsai-Wen Wan, Wataru Higuchi, Olga E. Khokhlova, Wei-Chun Hung, Yasuhisa Iwao, Masataka Wakayama, Noriyoshi Inomata, Tomomi Takano, Yu-Tzu Lin, Olga V. Peryanova, Kenji K. Kojima, Alla B. Salmina, Lee-Jene Teng, Tatsuo Yamamoto* (2017, Nov). Genomic comparison between Staphylococcus aureus GN strains clinically isolated from a familial infection case: IS1272 transposition through a novel inverted repeat-replacing mechanism. PLoS One, 12(11), e0187288. (SCI, IF=3.352; 15/64, Multidisciplinary sciences). 本人為第一作者.

13. Tsai-Wen Wan, Wei-Chun Hung, Jui-Chang Tsai, Yu-Tzu Lin, Hao Lee, Po-Ren Hsueh, Tai-Fen Lee, Lee-Jene Teng* (2016, Sep). Novel structure of Enterococcus faecium-originated ermB-positive Tn1546-Like element in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 60(10), 6108-6114. (SCI, IF=3.394; 36/257, Pharmacology & Pharmacy). MOST 103-2320-B-002-056-MY3. 本人為第一作者.

14. Wei-Chun Hung, Tsai-Wen Wan, Yu-Chia Kuo, Tatsuo Yamamoto, Jui-Chang Tsai, Yu-Tzu Lin, Po-Ren Hsueh, Lee-Jene Teng. Molecular evolutionary pathways toward two successful community-associated but multidrug-resistant ST59 methicillin-resistant Staphylococcus aureus lineages in Taiwan: dynamic modes of mobile genetic element salvages. PLoS One. 2016; 11(9), e0162526. [2015 IF=3.057; Multidisciplinary sciences (11/63, Q1)]. 第二作者.

15. Tsai-Wen Wan, Yusuke Tomita, Naoki Saita, Kanji Konno, Yasuhisa Iwao, Wei-Chun Hung, Lee-Jene Teng, T. Yamamoto. Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly. New Microbes and New Infections. 2016; 13, 17-21. [2023 IF=2.9; Microbiology (58/132, Q2)]. 共同第一作者.

 

16. Olga E. Khokhlova, Wei-Chun Hung, Tsai-Wen Wan, Yasuhisa Iwao, Tomomi Takano, Wataru Higuchi, Svetlana V. Yachenko, Olga V. Teplyakova, Vera V. Kamshilova, Yuri V. Kotlovsky, Akihito Nishiyama, Ivan V. Reva, Sergey V. Sidorenko, Olga V. Peryanova, Galina V. Reva, Lee-Jene Teng, Alla B. Salmina, Tatsuo Yamamoto. Healthcare-and community-associated methicillin-resistant Staphylococcus aureus (MRSA) and fatal pneumonia with pediatric deaths in Krasnoyarsk, Siberian Russia: unique MRSA's multiple virulence factors, genome, and stepwise evolution. PLoS One. 2015; 10(6), e0128017. [2014 IF=3.234; Multidisciplinary sciences (9/57, Q1)]. 第三作者

研討會論文

  • 1.    Xiang-Jun Chen, Bo-Wei Chen, Min-Hsuan Kuo, Tsai-Wen Wan, Hao-Chieh Chiu, Yu-Tsung Huang*. (2025, Dec). Integrating next-generation sequencing and machine learning to analyze molecular epidemiological characteristics of invasive and colonizing Streptococcus agalactiae. 台灣微生物學會第二十五屆第一次會員大會暨114年學術研討會, 台北, 台灣.

    2.    Tsai-Wen Wan*, Yu-Tsung Huang, Jian-Hong Lai, Hao-Chieh Chiu. (2025, Apr). Genomic population structure and adhesion-related virulence factors of invasive nontypeable Haemophilus influenzae isolates. 35th European Society of Clinical Microbiology and Infectious Diseases, Vienna, Austria. NSTC 111-2326-B-002-011-MY3.

    3.    Tsai-Wen Wan*, Jian-Hong Lai, Yu-Tsung Huang, Hao-Chieh Chiu. 2024. Comparative genomic insights into the population structure and pathogenicity of invasive nontypeable Haemophilus influenzae isolates. 第二十八屆細菌學研討會, 台南, 臺灣.

    4.    Tsai-Wen Wan*, Jian-Hong Lai, Yu-Tsung Huang, Hao-Chieh Chiu. 2024. Multidrug-resistant invasive nontypeable Haemophilus influenzae in Taiwan: molecular epidemiology, antimicrobial resistance mechanisms. European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2024, Barcelona, Spain.

    5.    Tsai-Wen Wan*, Yu-Tsung Huang, Hao-Chieh Chiu. 2023. Antibiotic susceptibility and molecular epidemiology of invasive nontypeable Haemophilus influenzae strains in northern Taiwan from 2011 to 2020. American Society for Microbiology (ASM) Microbe 2023, Houston, Texas, USA.

    6.    Tzu-Hsuan Liao, Hao-Chieh Chiu, Tsai-Wen Wan*. 2023. Daptomycin resistance mechanisms in Enterococcus faecium: Insights from whole-genome analysis. 第二十七屆細菌學研討會, 嘉義, 臺灣.

    7.    Jian-Hong Lai, Tsai-Wen Wan, Yu-Tsung Huang, Hao-Chieh Chiu. 2023. Analysis of virulence factors of non-typeable Haemophilus influenzae using third generation sequencing technology and comparative genomics. 第二十七屆細菌學研討會, 嘉義, 臺灣.

    8.    Tsai-Wen Wan*, Lee-Jene Teng, Tatsuo Yamamoto. 2019. Pathotypes and SCCmecIVl structures in ST8 community- associated methicillin-resistant Staphylococcus aureus. 日本細菌學學會,北海道,日本.

    9.    李俊立, 萬采玟, 林瑜姿, 王曉梅, 鄧麗珍. 2019. 金黃色葡萄球菌ST45spa type t1081non-t1081 的表現型及基因型分析. 台灣微生物學會, 台北, 臺灣.

    10. 李俊立, 萬采玟, 林瑜姿, 王曉梅, 鄧麗珍. 2018. 金黃色葡萄球菌ST45的表現型及基因型分析. 台灣微生物學會, 台北, 臺灣.

    11. 林怡君, 劉又榕, 萬采玟, 林瑜姿, 鄧麗珍. 2018. 抗紅黴素金黃色葡萄球菌ST834臨床菌株攜帶ermT基因結構之首次報告. 台灣微生物學會, 台北, 臺灣.

    12. Tsai-Wen Wan, Po-Ren Hsueh, LeeJene Teng. 2017. Emergence of ermB-carrying Tn1546-like element in methicillin-susceptible and methicillin-resistant Staphylococcus aureus. 美國微生物學會117屆年會, 紐奧良, 美國.

    13. Tsai-Wen Wan, Po-Ren Hsueh, LeeJene Teng. 2017. Emergence of Tn1546-ermB plasmid in methicillin-susceptible and methicillin-resistant Staphylococcus aureus. ICC (International Congress of Chemotherapy and Infection), 台北, 臺灣.

    14. Tsai-Wen Wan, Yu-Jung Liu, Yu-Tzu Lin, Hsin-Ni Huang, Tai-Fen Lee, Po-Ren Hsueh, LeeJene Teng.2016. Emergence of ermB-carrying Tn1546-like element in methicillin-susceptible and methicillin-resistant Staphylococcus aureus. 台灣微生物學會, 台北, 臺灣. (第一名)

    15. Tsai-Wen Wan, Wei-Chun Hung, LeeJene Teng. 2016. 新型Tn1546-like結構攜帶ermB基因出現於抗紅黴素金黃色葡萄球菌. 國立臺灣大學醫學院醫學檢驗暨生物技術學系, 台北. 臺灣. (佳作)

    16. Tsai-Wen Wan, Yu-Jung Liu, LeeJene Teng. 2015. Molecular typing of methicillin-susceptible Staphylococcus aureus and a complete sequence of plasmid harboring multi-resistance and toxin genes. 台灣微生物學會, 台北, 臺灣. (第一名) (口說)

    17. Tsai-Wen Wan, Wei-Chun Hung, LeeJene Teng. 2015. Genetic structures of erythromycin resistance genes in methicillin-susceptible Staphylococcus aureus. 細菌學研討會, 台南, 臺灣.

     

    18. Tsai-Wen Wan, Wei-Chun Hung, Tatsuo Yamamoto, LeeJene Teng. 2014. Complete genome sequence of a variant of the methicillin-resistant Staphylococcus aureus ST239 lineage, strain OC3, with the toxic shock syndrome toxin-1 gene. 細菌學研討會, 台南, 臺灣.

Go to top