Education

• 2008 PhD., Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University
• 2002 MS., Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University

Profession Experiences

• 2021 Associate professor, Department of Microbiology and Immunology, Kaohsiung Medical University, Kaohsiung, Taiwan
• 2020-2021 Associate Investigator, Translational Medicine Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan
• 2014-2019 Chief of Translational Medicine Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan
• 2008-2014 Associate Investigator, Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan

Research Topics

1. Pathogenesis study of dengue (Plasma leakage, viral replication, virvs infection vs. autophagy)
2. Investigation of tumorigenesis and tumor invasion (lung cancer, thyroid cancer, cholangiocarcinoma, etc.)
3. Evaluation of biological activity including natural products and synthetic compounds (antitumor and antiviral agents)
4. Specific biomarkers of human diseases (tumor, metabolic disease, and infectious disease)

Publications: (2017~2021)

1. Lee, Y. R.; Chang, C. M.; Yeh, Y. C.; Huang, C. F.; Lin, F. M.; Huang, J. T.; Hsieh, C. C.; Wang, J. R.; Liu, H. S.*, Honeysuckle Aqueous Extracts Induced let-7a Suppress EV71 Replication and Pathogenesis In Vitro and In Vivo and Is Predicted to Inhibit SARS-CoV-2. Viruses 2021, 13, (2).
2. Klionsky, D. J.; Abdel-Aziz, A. K.; Abdelfatah, S.; Abdellatif, M.; Abdoli, A.; Abel, S.; Abeliovich, H.; Abildgaard, M. H.; Abudu, Y. P.; Acevedo-Arozena, A.; Adamopoulos, I. E.; Adeli, K.; Adolph, T. E.; Adornetto, A., et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 2021, 17, (1), 1-382.
3. Kuo, C. H.; Lin, M. W.; Hsu, Y. W.; Chou, H. C.; Lin, L. H.; Law, C. H.; Lin, Y. C.; Hu, R. Y.; Kuo, W. H.; Ko, M. L.; Chang, S. J.; Lee, Y. R.*; Chan, H. L.*, Biomarker discovery in highly invasive lung cancer cell through proteomics approaches. Cell Biochem Funct 2021, 39, (3), 367-379.
4. Lee, Y. R.; Wu, S. Y.; Chen, R. Y.; Lin, Y. S.; Yeh, T. M.; Liu, H. S., Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection. Kaohsiung J Med Sci 2020, 36, (11), 911-919.
5. Chen, M. S.; Yeh, H. T.; Li, Y. Z.; Lin, W. C.; Lee, Y. R.; Tseng, Y. S.; Sheu, S. M., Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells. Int J Mol Sci 2020, 21, (15).
6. Huang, H. Y.; Chou, H. C.; Law, C. H.; Chang, W. T.; Wen, T. N.; Liao, E. C.; Lin, M. W.; Lin, L. H.; Wei, Y. S.; Tsai, Y. T.; Chen, H. Y.; Tan, K. T.; Kuo, W. H.; Ko, M. L., et al., Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. J Cell Mol Med 2020, 24, (17), 9737-9751.
7. Chang, J. M.; Kam, K. H.; Chao, W. Y.; Zhao, P. W.; Chen, S. H.; Chung, H. C.; Li, Y. Z.; Wu, J. Y.; Lee, Y. R.*, Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells. Int J Mol Sci 2020, 21, (12).
8. Chen, J. F.; Tsai, Y. T.; Lai, Y. H.; Lin, C. C.; Chou, H. C.; Kuo, W. H.; Ko, M. L.; Wei, Y. S.; Wang, Y. S.; Lin, M. W.; Chen, Y. J.; Lee, Y. R.*; Chan, H. L.*, Proteomic analysis of Antrodia Cinnamomea-induced ER stress in liver cancer cells. J Pharm Biomed Anal 2020, 187, 113142.
9. Tung, C. L.; Lin, M. W.; Hu, R. Y.; Chien, Y. C.; Liao, E. C.; Lin, L. H.; Chung, T. W.; Wei, Y. S.; Tsai, Y. T.; Chen, H. Y.; Chou, H. C.; Kuo, W. H.; Ko, M. L.; Chang, S. J., et al., Proteomic Analysis of Metastasis-Specific Biomarkers in Pancreatic Cancer: Galectin-1 Plays an Important Metastatic Role in Pancreatic Cancer. J Pharm Biomed Anal 2020, 186, 113300.
10. Tai, T. S.; Tien, N.; Shen, H. Y.; Chu, F. Y.; Wang, C. C. N.; Lu, C. H.; Yu, H. I.; Kung, F. P.; Chuang, H. H.; Lee, Y. R.; Chang, H. Y.; Lim, Y. P., Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRalpha) and Pregnane X Receptor (PXR). Evid Based Complement Alternat Med 2019, 2019, 9401648.
11. Lee, M. Y.; Shi, C. S.; Hsu, Y. C.; Huang, K. J.; Chen, S. H.; Zhao, P. W.; Chung, H. C.; Huang, Y. C.; Lee, Y. R.*, Honokiol Is a Potential Therapeutic Agent and Has a Synergistic Effect With 5-FU in Human Urothelial Cell Carcinoma Cells. Anticancer Res 2019, 39, (12), 6555-6565.
12. Yu, H. I.; Shen, H. C.; Chen, S. H.; Lim, Y. P.; Chuang, H. H.; Tai, T. S.; Kung, F. P.; Lu, C. H.; Hou, C. Y.; Lee, Y. R.*, Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment. Int J Mol Sci 2019, 20, (21).
13. Yeh, H. T.; Tsai, Y. S.; Chen, M. S.; Li, Y. Z.; Lin, W. C.; Lee, Y. R.; Tseng, Y. S.; Sheu, S. M., Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. Eur J Pharmacol 2019, 863, 172658.
14. Li, J. M.; Huang, Y. C.; Kuo, Y. H.; Cheng, C. C.; Kuan, F. C.; Chang, S. F.; Lee, Y. R.; Chin, C. C.; Shi, C. S., Flavopereirine Suppresses the Growth of Colorectal Cancer Cells through P53 Signaling Dependence. Cancers (Basel) 2019, 11, (7).
15. Jou, Y. C.; Wang, S. C.; Dai, Y. C.; Chen, S. Y.; Shen, C. H.; Lee, Y. R.; Chen, L. C.; Liu, Y. W., Gene expression and DNA methylation regulation of arsenic in mouse bladder tissues and in human urothelial cells. Oncol Rep 2019, 42, (3), 1005-1016.
16. Lee, M. Y.; Li, Y. Z.; Huang, K. J.; Huang, H. C.; Lin, C. Y.; Lee, Y. R.*, Indirubin-3'-oxime suppresses human cholangiocarcinoma through cell-cycle arrest and apoptosis. Eur J Pharmacol 2018, 839, 57-65.
17. Tsai, T. J.; Lim, Y. P.; Chao, W. Y.; Chen, C. C.; Chen, Y. J.; Lin, C. Y.; Lee, Y. R.*, Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration. Anal Cell Pathol (Amst) 2018, 2018, 8623937.
18. Yu, H. I.; Chou, H. C.; Su, Y. C.; Lin, L. H.; Lu, C. H.; Chuang, H. H.; Tsai, Y. T.; Liao, E. C.; Wei, Y. S.; Yang, Y. T.; Lee, Y. R.*; Chan, H. L.*, Proteomic analysis of evodiamine-induced cytotoxicity in thyroid cancer cells. J Pharm Biomed Anal 2018, 160, 344-350.
19. Chen, S. Y.; Lee, Y. R.; Hsieh, M. C.; Omar, H. A.; Teng, Y. N.; Lin, C. Y.; Hung, J. H., Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways. Front Pharmacol 2018, 9, 780.
20. Tsai, T. J.; Chao, W. Y.; Chen, C. C.; Chen, Y. J.; Lin, C. Y.; Lee, Y. R.*, Gelsolin-like Actin-capping Protein (CapG) Overexpression in the Cytoplasm of Human Hepatocellular Carcinoma, Associated with Cellular Invasion, Migration and Tumor Prognosis. Anticancer Res 2018, 38, (7), 3943-3950.
21. Chou, H. C.; Lu, C. H.; Su, Y. C.; Lin, L. H.; Yu, H. I.; Chuang, H. H.; Tsai, Y. T.; Liao, E. C.; Wei, Y. S.; Yang, Y. T.; Chien, Y. A.; Yu, X. R.; Lee, Y. R.*; Chan, H. L.*, Proteomic analysis of honokiol-induced cytotoxicity in thyroid cancer cells. Life Sci 2018, 207, 184-204.
22. Lin, C. C.; Wu, J. J.; Pan, Y. G.; Chao, Y. H.; Lin, F. C.; Lee, Y. R.; Chu, C. L., Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine. J Sci Food Agric 2018, 98, (14), 5509-5517.
23. Huang, K. J.; Kuo, C. H.; Chen, S. H.; Lin, C. Y.; Lee, Y. R.*, Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy. J Cell Mol Med 2018, 22, (3), 1894-1908.
24. Lee, Y. R.; Chen, S. H.; Lin, C. Y.; Chao, W. Y.; Lim, Y. P.; Yu, H. I.; Lu, C. H., In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis. Int J Mol Sci 2018, 19, (1).
25. Lee, Y. R.; Kuo, S. H.; Lin, C. Y.; Fu, P. J.; Lin, Y. S.; Yeh, T. M.; Liu, H. S., Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo. Sci Rep 2018, 8, (1), 489.
26. Lee, Y. R.; Tien, N. I.; Lin, C. L.; Shen, H. Y.; Bau, D. T.; Lim, Y. P., Association of Antituberculosis Treatment and Lower Risk of Hyperlipidemia in Taiwanese Patients: A Population-Based Case-Control Study. In Vivo 2018, 32, (1), 47-54.
27. Chang, H. Y.; Chen, C. J.; Ma, W. C.; Cheng, W. K.; Lin, Y. N.; Lee, Y. R.; Chen, J. J.; Lim, Y. P., Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity. Phytomedicine 2017, 36, 37-49.
28. Lin, Y. N.; Chen, C. J.; Chang, H. Y.; Cheng, W. K.; Lee, Y. R.; Chen, J. J.; Lim, Y. P., Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity. J Agric Food Chem 2017, 65, (39), 8606-8616.
29. Yang, C. S.; Wei, Y. S.; Tsai, H. L.; Cheong, I. S.; Chang, S. J.; Chou, H. C.; Lee, Y. R.*; Chan, H. L.*, Proteomic analysis of prognostic plasma biomarkers in peripheral arterial occlusive disease. Mol Biosyst 2017, 13, (7), 1297-1303.
30. Shi, C. S.; Li, J. M.; Chin, C. C.; Kuo, Y. H.; Lee, Y. R.*; Huang, Y. C.*, Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells. Anticancer Res 2017, 37, (3), 1149-1159.