Pei-Yi (Alma) Su

蘇倍儀 

I have recently been appointed as an Assistant Professor in Medical Sciences at Kaohsiung Medical University, School of Medicine. My academic responsibilities include teaching virology and related biomedical subjects to medical students, as well as pursuing independent research in the field of virus–host interactions and RNA biology. My work bridges basic science and translational medicine, aiming to better understand viral pathogenesis and identify potential therapeutic targets.

Education

Doctor of Philosophy

Taiwan International Graduate Program in Molecular Medicine (TIGP-MM)

National Yang Ming University and Academia Sinica

Institute of Biochemistry and Molecular Biology

Profession Experiences

  • Assistant Professor, Department of Microbiology and Immunology, School of Medicine, Kaohsiung Medical University (Aug 2025 ~ Present)
  • Postdoctoral Research Fellow, Institute of Biomedical Sciences, Academia Sinica (Oct 2018 ~ July 2025)

Research Directions

1.     Decoding the role of RNA modifications in viral replication and host-virus interactions, using integrative approaches that combine molecular virology, RNA biology, and next-generation sequencing

2.   Development of next-generation antimicrobial peptides (AMPs) targeting multidrug-resistant (MDR) microbes

Related Research Reports

Publications

1.  Pei-Yi (Alma) Su, Chih-Hsu Chang, Shin-Chwen Bruce Yen, Hsiu-Yi Wu, Wan-Ju Tung, Yu-Pei Hu, Yen-Yu Ian Chen, Miao-Hsia Lin, Chiaho Shih, Pei-Jer Chen, Kevin Tsai: Epitranscriptomic cytidine methylation of the Hepatitis B viral RNA is essential for viral reverse transcription & particle production. Proceedings of the National Academy of Sciences (PNAS) 2024;121 (24) e2400378121. DOI: https://doi.org/10.1073/pnas.2400378121 

2.  Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin, Chiaho Shih: Hepatitis B virus virion secretion is a CRM1-spike-mediated late event. Journal of Biomedical Science 2022; DOI: https://doi.org/10.1186/s12929-022-00827-w

3.  Pei-Yi Su, Chiaho Shih:Chap 16: Emerging New Therapies for Viral Hepatitis. Viral Hepatitis in Children 2019; ISBN 978-981-13-0049-3, Springer Nature Singapore. DOI: https://doi.org/10.1007/978-981-13-0050-9_16

4.  Heng-Li Chen, Pei-Yi Su, Shu-Chen Kuo, Tsai-Ling Lauderdale, Chiaho Shih: Adding a C-terminal cysteine (CTC) can enhance the bactericidal activity of three different antimicrobial peptides. Frontiers in Microbiology 2018; 9:1440. DOI: https://10.3389/fmicb.2018.01440

5.  Pei-Yi Su, Ching-Jen Yang, Tien-Hua Chu, Chih-Hsu Chang, Chiayn Chiang, Fan-Mei Tang, Chih-Yin Lee, Chiaho Shih:HBV maintains electrostatic homeostasis by modulating negative chargesfrom phosphoserine and encapsidated nucleic acids. Scientific Reports 2016; 6: DOI: 10.1038/srep38959

6.  Heng-Li Chen, Pei-Yi Su, Chiaho Shih: Improvement of in vivo antimicrobial activity of HBcARD peptides by D-arginine replacement.Applied Microbiology and Biotechnology 2016; DOI: 10.1007/s00253-016-7621-6

7.  Ching-Chun Yang, Er-Yi Huang, Hung-Cheng Li, Pei-Yi Su, Chiaho Shih: Nuclear Export of Human Hepatitis B Virus Core Protein and Pregenomic RNA Depends on the Cellular NXF1-p15 Machinery. PLoS ONE 2014; 9(10):e106683. DOI:10.1371/journal.pone.0106683

8.  Tien-Hua Chu, An-Ting Liou, Pei-Yi Su, Huey-Nan Wu, Chiaho Shih: Nucleic Acid Chaperone Activity Associated with the ARD Domain of Human Hepatitis B Virus Core Protein. Journal of Virology 2013; 88(5). DOI:10.1128/JVI.03235-13

9.   Heng-Li Chen, Pei-Yi Su, Ya-Shu Chang, Szu-Yao Wu, You-Di Liao, Hui-Ming Yu, Tsai-Ling Lauderdale, Kaichih Chang, Chiaho Shih: Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD). PLoS Pathogens 2013; 9(6):e1003425. DOI:10.1371/journal.ppat.1003425

10.Hung-Cheng Li, Er-Yi Huang, Pei-Yi Su, Szu-Yao Wu, Ching-Chun Yang, Young-Sun Lin, Wen-Chang Chang, Chiaho Shih: Nuclear Export and Import of Human Hepatitis B Virus Capsid Protein and Particles. PLoS Pathogens 2010; 6(10):e1001162. DOI:10.1371/journal.ppat.1001162

11.Kai-Wen Huang, Hui-Lin Wu, Hsiu-Lin Lin, Po-Chin Liang, Pei-Jer Chen, Shih-Hui Chen, Hsin-I Lee, Pei-Yi Su, Wen-Hsuan Wu, Po-Huang Lee, Lih-Hwa Hwang, Ding-Shinn Chen: Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model. Proceedings of the National Academy of Sciences (PNAS) 2010; 107(33):14769-74. DOI:10.1073/pnas.1009534107

12.Margaret Newman, Pong Kian Chua, Fan-Mei Tang, Pei-Yi Su, Chiaho Shih: Testing an Electrostatic Interaction Hypothesis of Hepatitis B Virus Capsid Stability by Using an In Vitro Capsid Disassembly/Reassembly System. Journal of Virology 2009; 83(20):10616-26. DOI:10.1128/JVI.00749-09

Patents

1.  Chiaho Shih, Heng-Li Chen, Pei-Yi Su: Modified antimicrobial peptide derived from an arginine-rich domain. USA Patent, US12084479B2

2.  Chiaho Shih, Heng-Li Chen, Pei-Yi Su: 아르기닌이 풍부한 도메인(Arginine-Rich domain)으로부터 유도된 변형된 항균성 펩타이드. South Korea Patent, KR102530478B1

3.  Chiaho Shih, Heng-Li Chen, Pei-Yi Su: アルギニンリッチドメインに由来する改変抗微生物ペプチド. Japan Patent, 特願JP2018-561017

4.  Chiaho Shih, Heng-Li Chen, Pei-Yi Su: Modified antimicrobial peptide derived from an arginine-rich domain. South Africa Patent, ZA 201807763B

5.  Chiaho Shih, Heng-Li Chen, Pei-Yi Su: Antimicrobial peptides derived from hepatitis B virus core protein arginine–rich domain. USA Patent, US10214564B2; US10752657B2

6.  施嘉和、陳恆立、蘇倍儀: 衍生自精胺酸密集區之經修飾抗菌胜肽. Taiwan Patent, TWI635095

7.  施嘉和、陈恒立、苏倍仪: 衍生自 B 型肝炎病毒核蛋白精氨酸密集区的抗菌胜肽. People’s Republic of China Patent, CN2509804

8.  施嘉和、陳恆立、蘇倍儀: 衍生自B型肝炎病毒核蛋白精胺酸密集區之抗菌胜肽.Taiwan Patent, TWI495642

9.  施嘉和、陈恒立、苏倍仪: 衍生自精氨酸密集区之经修饰抗菌胜肽.People’s Republic of China Patent, CN109641938A

10. Chiaho Shih, Heng-Li Chen, Pei-Yi Su: Antimicrobial peptides derived from hepatitis B virus core protein arginine-rich domain. Europe Patent, EP2986115A1 (Pending)

Awards & Grants

2025        2025 HBV International Meeting Travel Grant, Berlin, Germany

2024        RiboClub Travel Award, RNA Canada 2024

2023        IBMS Institutional Research Day Best Oral Presentation Award, Academia Sinica

2023        2023 HBV International Meeting Travel Grant, Kobe, Japan

2023        RNA Society Research Presentation Fellowship, RNA 2023, Singapore

2020        Post-Doctoral Fellowship, Ministry of Science and Technology, Taiwan

2019       Meeting Travel Award for Early-Career Scientists, Hepatitis B Foundation,

USA

2017        Travel Grant, the 9th HOPE meeting with Nobel Laureates, JSPS (日本学

術振興会), Japan and Academia Sinica, Taiwan

2016        IBMS Travel Grant, Academia Sinica, Taiwan     

2016        Meeting Travel Award for Young Scientists, Hepatitis B Foundation, USA

2015        Travel Grant, Ministry of Science and Technology, Taiwan

2015        Meeting Travel Award for Young Scientists, Hepatitis B Foundation, USA

2013        Travel Grant, Ministry of Science and Technology, Taiwan

2013        TIGP Travel Grant, Academia Sinica, Taiwan

2011        Travel Grant, Ministry of Science and Technology, Taiwan

2011        IBMS Research Award, Academia Sinica, Taiwan

Conference Proceedings

1.   Pei-Yi (Alma) Su, Yun-Hua Lin, Shania Foustine, Chih-Hsu Chang, Redmond P Smyth, Marcos Morgan, Pei-Jer Chen, Kevin Tsai: Direct RNA sequencing reveals m6A-dependent stabilization of hepatitis B virus RNA. 2025 HBV international meeting, Berlin, Germany, Sep 8-12, 2025 (Oral)

2.   Pei-Yi (Alma) Su, Chih-Hsu Chang, Shin-Chwen Bruce Yen, Hsiu-Yi Wu, Wan-Ju Tung, Yu-Pei Hu, Yen-Yu Ian Chen, Miao-Hsia Lin, Chiaho Shih, Pei-Jer Chen, Kevin Tsai: Epitranscriptomic cytidine methylation of the Hepatitis B viral RNA is essential for viral reverse transcription & particle production. RNA Canada 2024, Ottawa, Canada, Sep 30-Oct 04 2024 (Flash Talk/Poster)

3.   Pei-Yi (Alma) Su, Shin-Chwen Bruce Yen, Chih Hsu Chang, Wan-Ju Tung, Hsiu-Yi Wu, Kevin Tsai: Epitranscriptomic cytidine methylations on HBV pgRNA ensure efficient virion packaging and reverse transcription. 2023 HBV international meeting, Kobe, Japan, Sep 19-23 2023 (Oral)

4.   Pei-Yi (Alma) Su, Shin-Chwen Bruce Yen, Wan-Ju Tung, Hsiu-Yi Wu, Kevin Tsai:  Epitranscriptomic cytidine methylations ensure the packaging and subsequent reverse transcription of Hepatitis B virus genomic RNA. RNA Society Meeting 2023, Singapore, May 30-June 04 2023 (Poster)

5.   Szu-Yao Wu, Pei-Yi Su, Ya-Shu Chang, Tien-Hua Chu, and Chiaho Shih: Prolonged persistence of HBV DNA and genome maturation in a mouse model. 2019 HBV international meeting, Melbourne, Australia, Oct 01-05, 2019 (Oral)

6.   Pei-Yi Su: Electrostatic homeostasis in hepatitis B virus capsid biology. The 9th HOPE meeting with Nobel Laureates, Tokyo, Japan, Feb 25-Mar 3, 2017 (Oral / Poster)

7.   Pei-Yi Su, Chih-Hsu Chang, Ching-Jen Yang, Tien-Hua Chu, Chiayn Chiang, Fan-Mei Tang, Chih-Yin Lee, Chiaho Shih: Serine phosphorylation of hepatitis B virus core protein modulates balanced electrostatic interactions important in HBV life cycle. 2016 HBV international meeting, Yonsei University, Seoul, Korea, Sep 21-24, 2016 (Oral)

8.   Ching-Jen Yang, Pei-Yi Su, Ching-Chun Yang, Chiaho Shih: Pregenomic RNA encapsidation modulates subcellular trafficking of hepatitis B virus core protein in the context of active viral replication. 2015 HBV international meeting, Dolce Bad Nauheim, Germany, Oct 4-8, 2015 (Poster)

9.   Pei-Yi Su, Ching-Jen Yang, Tien-Hua Chu, Chiayn Chiang, Chih-Yin Lee, Chiaho Shih: Electrostatic interactions between HBV core protein and encapsidated nucleic acid in HBV capsid assembly, RNA packaging, and DNA synthesis. 2013 HBV international meeting, Shanghai Medical College Fudan University, China, Oct 20-23, 2013 (Oral)

10.  Pei-Yi Su, Fan-Mei Tang, Chiayn Chiang, Chih-Yin Lee, Jyun-Yuan Huang, Chiaho Shih: Further testing of the charge balance/imbalance hypothesis of hepatitis B virus in reverse transcription, capsid assembly and morphogenesis. 2011 HBV international meeting, Lake Buena Vista, Florida, USA, Oct 9-12, 2011 (Poster)

11.  Pei-Yi Su, Fan-Mei Tang, Tien-Hua Chu, Chiaho Shih: Balanced electrostatic interaction hypothesis of hepatitis B virus capsid assembly and disassembly. 2010 HBV international meeting, Academia Sinica, Taiwan, Oct 9-13, 2010 (Oral)

12.  Pei-Yi Su, Fan-Mei Tang, Chiayn Chiang, Chih-Yin Lee, Jyun-Yuan Huang, Chiaho Shih: Testing the charge balance hypothesis of hepatitis B virus DNA synthesis using an in vivo charge re-balance approach in a full-length HBV core context. 2010 HBV international meeting, Academia Sinica, Taiwan, Oct 9-13, 2010 (Poster)

 

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